The hand picks what it loves and favors. When you are hand-picked it could be that you are loved and favored. Favor also encompasses separation from the rest, because it removes you from your comfort zone and sets a clear difference between you and those you are on the same level with.
Let’s take an example of a beautiful flower. It is the most beautiful and outstanding amongst many other flowers but because it finds favor with its owner it is handpicked and plucked out from the rest of its kind. This is both wonderful and painful at the same time because that is what being unique comes with, you become separated from the rest. But this handpicking, in as much as it is painful it comes with so much positive benefits. Your uniqueness attracts great things and opportunities and as that beautiful flower you create another new breed of unique flowers like you, hence God handpicked you because you found favor in His sight.
In my own personal experience of being handpicked, came the joy of realising that I am unique and different from others. When His hand is upon me, what more would I ask for. However, as one begins to rise out of that basket, you suddenly begin to feel the separation. In that moment of separation, comes rejection as no one reaches to you often, and few may understand why you are in that place that you have being selected to be in. So questions start arising within you, asking yourself what’s wrong with everything, why am i alone? You take a good look at the man in the mirror and realise not only are you talented and good looking, you don't seem to have anyone around you cheering you on?
When the Lord's hand is upon you and He places you in that position He handpicked you, there comes a sense of belonging. Like a flower picked and placed before an audience that is captured by who you have become, everything begins to make sense. You begin to understand those moments of separation and rejection from your own kind.
If you have a special purpose, expect these kinds of moments. All great men and women who have ever achieved great things in order for them to be outstanding had to stop following the crowd to follow their passions. If they kept following the crowd they might have been discouraged about their vision. This is why being handpicked is important, it separates you from the rest and prepares you for your special purpose.